Qwen2.5 72B Instruct: how much VRAM does it need?
Qwen2.5 72B Instruct has 72.70B parameters in 80 layers. It uses grouped-query attention: 64 query heads share 8 key-value heads, so its KV cache is 8× smaller than full multi-head attention would need. It takes up to 32,768 tokens of context; one user at that length needs 10.00 GiB of KV cache at FP16 on top of the weights.
135.4 GiB of weights, 2.50 GiB of KV cache and 4.12 GiB of vLLM's overhead. At INT4 the same workload needs 45.99 GiB.
- 80 layers
- hidden 8192
- 64/8 heads
- head_dim 128
- 32k max context
Qwen2.5 72B Instruct memory by precision and context
| Precision | 8k context | 32k context |
|---|---|---|
| BF16 | 142.0 GiBKV cache 2.50 GiB | 149.5 GiBKV cache 10.00 GiB |
| FP8 | 76.64 GiBKV cache 2.50 GiB | 84.14 GiBKV cache 10.00 GiB |
| INT4 | 45.99 GiBKV cache 2.50 GiB | 53.49 GiBKV cache 10.00 GiB |
One user, FP16 KV cache and vLLM's overhead on one GPU at its defaults for a card under 70 GB. Quantizing shrinks the weights, not the KV cache, so the saving narrows as the context grows.
Which single GPUs hold it
- BF16 (142.0 GiB): Apple M2 Ultra, B200 180GB, AMD MI300X, Apple M3 Ultra (256GB)
- FP8 (76.64 GiB): H100 NVL 94GB, GH200 96GB, RTX PRO 6000 Blackwell, RTX PRO 6000 Blackwell Server
- INT4 (45.99 GiB): Apple M4 Max (64GB), NVIDIA Jetson AGX Orin (64GB), AMD MI210, RTX PRO 5000 Blackwell (72GB)
At 8k context for one user, the smallest cards first. A discrete card is budgeted at vLLM's default 92% of its memory, a unified-memory device at the share its GPU can address, and each carries vLLM's overhead at its own defaults.
How many users fit
| GPU | BF16 | FP8 | INT4 |
|---|---|---|---|
| RTX 4090 | does not fit | does not fit | does not fit |
| RTX 5090 | does not fit | does not fit | does not fit |
| RTX 6000 Ada | does not fit | does not fit | does not fit |
| H100 SXM 80GB | does not fit | does not fit | 11 |
| RTX PRO 6000 Blackwell | does not fit | 5 | 17 |
| AMD Ryzen AI Max+ 395 (128GB) | does not fit | 5 | 17 |
| H200 141GB | does not fit | 21 | 33 |
| B200 180GB | 8 | 34 | 46 |
Users at 8k context each, on one card. ✗: the weights leave no room for even one.
Fine-tuning Qwen2.5 72B Instruct
| Method | Memory | Smallest GPU |
|---|---|---|
| Full fine-tune | 1086.8 GiB | several GPUs, sharded |
| LoRA (rank 16, attention) | 139.8 GiB | Apple M2 Ultra |
| QLoRA (rank 16, attention) | 39.29 GiB | NVIDIA L40S |
Sequence length 2,048, batch size 1, gradient checkpointing on, Adam. Full fine-tuning keeps 16 bytes per parameter before activations; QLoRA stores the frozen base in 4-bit NF4.
Where the numbers come from
Weights are parameters × bytes per parameter. The KV cache is 2 × layers × key-value heads × head dimension × bytes × context × users. For Qwen2.5 72B Instruct that is 320.0 KiB per token at FP16. These are capacity-planning figures: the serving engine — vLLM, TGI, llama.cpp — and its paged-attention efficiency still move the real number.
More on KV cache size and on GQA, MQA and MLA.
Work with Qwen2.5 72B Instruct
- Size it for your workload
- Fine-tuning memory
- vLLM parameters
- Model anatomy
- Its config.json, explained
- What its files say about serving it